![]() In addition, with more knowledge of regulatory mechanisms, induction of ferroptosis could be harnessed to control tumor growth. Understanding ferroptosis is important because this type of cell death is associated with disease states such as neurodegeneration and various renal, liver, and lung diseases. These studies highlight a potentially beneficial role for endogenous and dietary MUFAs in the prevention of ferroptosis.įerroptosis is a regulated form of cell death driven by excess production of lipid peroxides. Furthermore, our studies reveal important differences in how dietary lipids influence germ cell ferroptosis versus whole-body peroxide-induced oxidative stress. Specifically, we reduced ferroptosis sensitivity by (1) using mutant strains unable to synthesize DGLA, (2) using a strain carrying a gain-of-function mutation in the transcriptional mediator MDT-15, or (3) by dietary supplementation of MUFAs. We demonstrate that ferroptosis sensitivity in both wild type and ether-lipid deficient mutants can be rescued in several ways that change the relative abundance of saturated fats, MUFAs and specific polyunsaturated fatty acids (PUFAs). elegans, leading to altered ratios of saturated and monounsaturated fatty acid (MUFA) content in cellular membranes. Instead, we demonstrate that ether lipid-deficiency disrupts lipid homeostasis in C. We found no role for plasmalogens in either process. elegans mutants to test the hypothesis that the vinyl ether bond in plasmalogens acts as an antioxidant to protect against germ cell ferroptosis as well as to protect from whole-body tert-butyl hydroperoxide (TBHP)-induced oxidative stress. The vinyl ether bond unique to plasmalogen lipids has been hypothesized to function as an antioxidant, but this has not been tested in animal models. We also demonstrated that ether lipid-deficient mutant strains are sensitive to DGLA-induced ferroptosis, suggesting a protective role for ether lipids. Previously, we showed that dietary dihomo-gamma-linolenic acid (DGLA 20: 3(n-6)) triggers ferroptosis in the germ cells of the model organism, Caenorhabditis elegans. Available in sizes of 8.5"x11", 12"x12", 8.5"x24" and 8.Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled membrane lipid peroxidation and destruction.Compatible with all craft cutters such as: Cricut, Silhouette, Xyron, Craft ROBO, Graphtec, Quickutz, Inspirations, Pazzles, etc.Water Resistant (hand wash recommended).Outdoor Durability: 1 year (without a laminate).Shelf Life: 1 year (at 70 F/50% relative humidity).It can be used indoors but is water and weather resistant making it an ideal craft vinyl choice for outdoor applications as well. It is compatible with all personal hobby and craft cutters and can be used in many applications including windows, car decals, signs, scrapbooking or any application where a printed pattern or design is desired. These inkjet printable vinyl sheets are compatible with any inkjet printer and when combined with print and cut features of machines such as the Silhouette Cameo or Cricut Explore an inkjet printable vinyl sheet can give you the stunning results you desire.Īll of our vinyl comes with an adhesive on one side with a paper backing that protects the adhesive until exposed. #EXPRESSIONS VINYL PROFESSIONAL#All it takes is a home inkjet printer and your favorite digital electronic cutter to begin creating professional quality results at home. ![]()
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